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  <xs:element id="aqst_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedForfeituresAndExpirationsInPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedForfeituresAndExpirationsInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="aqst_SecuritiesPurchaseAgreementMember" abstract="true" name="SecuritiesPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_SalesRelatedAllowancesAndAccrualsTableTextBlock" abstract="false" name="SalesRelatedAllowancesAndAccrualsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="aqst_ManufacturingAndSupplyMember" abstract="true" name="ManufacturingAndSupplyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_InventoryPackingMaterialGross" abstract="false" name="InventoryPackingMaterialGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_ConsultingFee" abstract="false" name="ConsultingFee" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_TradeAndOtherReceivablesNet" abstract="false" name="TradeAndOtherReceivablesNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_AccountsReceivableAllowancesCreditsAndPayments" abstract="false" name="AccountsReceivableAllowancesCreditsAndPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_NetProceedsAfterPlacementAgentFeesExpensesAndOfferingExpensesPayable" abstract="false" name="NetProceedsAfterPlacementAgentFeesExpensesAndOfferingExpensesPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_AccountsReceivableAllowancesAndAccruals" abstract="false" name="AccountsReceivableAllowancesAndAccruals" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_NumberOfOperatingLeases" abstract="false" name="NumberOfOperatingLeases" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="aqst_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognizedNoncurrent" abstract="false" name="TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognizedNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_SharesOfCommonStockToBePurchasedByCommonStockWarrants" abstract="false" name="SharesOfCommonStockToBePurchasedByCommonStockWarrants" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="aqst_SupplementalAgreementWithIndiviorPerformanceOrEventBasedMilestonesMember" abstract="true" name="SupplementalAgreementWithIndiviorPerformanceOrEventBasedMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_ClassOfWarrantOrRightWarrantsExercised" abstract="false" name="ClassOfWarrantOrRightWarrantsExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="aqst_PercentOfFairValueOfSharesEmployeesPurchase" abstract="false" name="PercentOfFairValueOfSharesEmployeesPurchase" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="aqst_CumulativeRoyaltyReceivable" abstract="false" name="CumulativeRoyaltyReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_ComputerNetworkEquipmentAndSoftwareMember" abstract="true" name="ComputerNetworkEquipmentAndSoftwareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_ResearchAndDevelopmentProjectDuration" abstract="false" name="ResearchAndDevelopmentProjectDuration" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aqst_FirstSevenMonthsMember" abstract="true" name="FirstSevenMonthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_LicenseAgreementTerm" abstract="false" name="LicenseAgreementTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aqst_WarrantExercisesMember" abstract="true" name="WarrantExercisesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_AccountsReceivableAllowancesAndAccrualsTradeAndOtherReceivablesNet" abstract="false" name="AccountsReceivableAllowancesAndAccrualsTradeAndOtherReceivablesNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsEstimatedGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsEstimatedGrantDateFairValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="aqst_DurationOfPaymentDomain" abstract="true" name="DurationOfPaymentDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_ClassOfWarrantOrRightWarrantsIssuedDuringPeriod" abstract="false" name="ClassOfWarrantOrRightWarrantsIssuedDuringPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="aqst_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInShares" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="aqst_NeurelisIPRLitigationMember" abstract="true" name="NeurelisIPRLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_ContingentPaymentsReceivableInTheFuture" abstract="false" name="ContingentPaymentsReceivableInTheFuture" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_CashPaymentRepresenting90DaysOfBasePay" abstract="false" name="CashPaymentRepresenting90DaysOfBasePay" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_DebtInstrumentPrincipalNumberOfQuarterlyPayments" abstract="false" name="DebtInstrumentPrincipalNumberOfQuarterlyPayments" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="aqst_RoyaltyObligationActivityTableTextBlock" abstract="false" name="RoyaltyObligationActivityTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="aqst_LincolnParkAgreementMember" abstract="true" name="LincolnParkAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_ProceedsFromIssuancePrivateOffering" abstract="false" name="ProceedsFromIssuancePrivateOffering" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_UnvestedRestrictedStockUnitsMember" abstract="true" name="UnvestedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_SharesOfCommonStockEntitledToPurchasersByPreFundedWarrants" abstract="false" name="SharesOfCommonStockEntitledToPurchasersByPreFundedWarrants" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="aqst_ProceedsFromSaleOfFutureRevenuesNet" abstract="false" name="ProceedsFromSaleOfFutureRevenuesNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_SaleOfFutureRevenueTextBlock" abstract="false" name="SaleOfFutureRevenueTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="aqst_ProprietaryProductSalesMember" abstract="true" name="ProprietaryProductSalesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_AgreementTerm" abstract="false" name="AgreementTerm" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aqst_TwelvePointFiveSeniorSecuredNotesDueJune302025Member" abstract="true" name="TwelvePointFiveSeniorSecuredNotesDueJune302025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_SecondAdditionalOfferingMember" abstract="true" name="SecondAdditionalOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aqst_SaleOfStockAggregateOfferingPrice" abstract="false" name="SaleOfStockAggregateOfferingPrice" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aqst_WarrantsDisclosureTextBlock" abstract="false" name="WarrantsDisclosureTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="aqst_NumberOfGuaranteedRoyaltyPayments" abstract="false" name="NumberOfGuaranteedRoyaltyPayments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
</xs:schema>
